Empowering neurodevelopmental studies through benchmarking and modeling

Tuesday, April 27, 2021 - 11:00am to 12:00pm

When: Tuesday, April 27, 11:00-12:00

https://zoom.us/j/98717098004?pwd=T3lPSGZ2K1pKTllQaWhRMDBtNVcrUT09

Speaker: Dr. Christian O’Reilly, McGill University, Canada

Talk abstract: Modeling is the bedrock on which science and technology have been built. Nowadays, almost every part of manufactured objects – may it be a supercomputer or a simple light bulb -- is modeled and simulated for us to gain a comprehensive understanding of how it works and how it will react under different conditions. Compared to human-made objects, our ability to get a grip on complex biological systems such as the brain has been hindered by these systems being black boxes which inner workings were mostly unknown. As we gain more insights on the mechanisms at play, our capacity to model and simulate these systems increases and further shed light on their remaining mysteries. In parallel, as the advances in medicine and science provide us with a finer appreciation of these biological systems, it also generates more intricate challenges. Tackling these new problems often requires integrating many sources of knowledge across fields and scales, from slow-evolving social factors to millisecond molecular interactions. Understanding complex multi-factorial and multidimensional neurodevelopmental issues like those present in the autistic spectrum disorder is such a problem. In this context, setting up a solid analytical framework empowered by modeling and simulation is even more important. In the first half of this talk I will go over some of my experiences in analyzing and modeling neuronal systems at different scales, from the macroscopic whole-brain scale to the microscopic cellular scale. Then, in the second part, building on these experiences I will make a case for the importance of systematically benchmarking the different aspects of the brain across scales and integrating such knowledge into analytical tools that we can use for scientific discoveries and clinical decisions.

Speaker bio (short): Christian O’Reilly (Google Scholar) received his B.Ing (electrical eng.; 2007), his M.Sc.A. (biomedical eng.; 2011), and his Ph.D. (biomedical eng.; 2012) from the École Polytechnique de Montréal where he worked under the mentoring of Pr. R. Plamondon to apply pattern recognition and machine learning to predict brain stroke risks. He was later a postdoctoral fellow in Pr. T. Nielsen’s laboratory at the Center for Advanced Research in Sleep Medicine of the Hôpital du Sacré-Coeur/Université de Montréal (2012-2014) and then a NSERC postdoctoral fellow at McGill's Brain Imaging Center (2014-2015) where he worked in Pr. Baillet’s laboratory on characterizing EEG sleep transients, their sources, and their functional connectivity. During this period, he also was a visiting scholar in Pr. K. Friston's laboratory at the University College of London to study effective connectivity during sleep transients using dynamic causal modeling, an approach based on the Bayesian inversion of neural mass models. He later took on a 6-month fellowship with the Pr. M. Elsabbagh on functional connectivity in autism after which he moved to Switzerland to work for the Blue Brain project (Pr. S. Hill; EPFL; 2015-2018) where he led efforts on large-scale biophysically detailed modeling of the thalamocortical loop. Since 2020, he resumed his collaboration with the Dr. Elsabbagh as a research associate at the Azrieli Centre for Autism Research (McGill) where he is studying brain connectivity in autism and related neurodevelopmental disorders.