Dan Reed, University of North Carolina at Chapel Hill Renaissance Computing: The Interdisciplinary Future Abstract: Legend says that Archimedes remarked, on the discovery of the lever, "Give me a place to stand, and I can move the world." As an intellectual lever, computing allows researchers and practitioners to bring to life theoretical models of phenomena when economics or other constraints preclude experimentation. Computing also allows us to capture and analyze the torrent of experimental data being produced by a new generation of scientific instruments and sensors, themselves made possible by advances in computing and microelectronics. Finally, computing, via high-speed networks and distributed collaboration systems, brings people and talent together across the barriers of time and space. Simply put, computing pervades all aspects of science and engineering - "science" and "computational science" have become largely synonymous. However, we face major challenges. Systems built from commodity processors dominate high-performance computing today, with systems containing thousands of processors now being deployed. Similarly, large-scale Grids containing hundreds of thousands of sites are being contemplated, developed and deployed. As node counts for multi-teraflop systems grow to tens of thousands, with proposed petaflop systems likely to contain hundreds of thousands of nodes, we must rethink traditional assumptions about software scaling and manageability and hardware reliability. This talk will examine a set of interdisciplinary application domains and the implications of those domains for system scalability, fault tolerance and next generation technology.